Search Clinical Trials
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Emergency Preservation and Resuscitation (EPR) for Cardiac Arrest From Trauma
University of Maryland, Baltimore
Cardiac Arrest From Trauma
The goal of this study is to rapidly cool trauma victims who have suffered cardiac arrest
from bleeding with a flush of ice-cold sodium chloride to preserve the patient to enable
surgical control of bleeding, followed by delayed resuscitation with cardiopulmonary
bypass. expand
The goal of this study is to rapidly cool trauma victims who have suffered cardiac arrest from bleeding with a flush of ice-cold sodium chloride to preserve the patient to enable surgical control of bleeding, followed by delayed resuscitation with cardiopulmonary bypass. Type: Interventional Start Date: Oct 2016 |
MRgFUS Pallidotomy for the Treatment of Task Specific Focal Hand Dystonia (TSFD)
University of Maryland, Baltimore
Task-Specific Focal Dystonia
The purpose of this study is to assess the safety and effectiveness of MRI-guided focused
ultrasound (MRgFUS) for treating task specific focal hand dystonias (TSFD). TSFD is a
type of dystonia that affects hand movements during specific tasks such as writing,
playing instruments or typing, often causing... expand
The purpose of this study is to assess the safety and effectiveness of MRI-guided focused ultrasound (MRgFUS) for treating task specific focal hand dystonias (TSFD). TSFD is a type of dystonia that affects hand movements during specific tasks such as writing, playing instruments or typing, often causing involuntarily movements or cramping. Type: Interventional Start Date: Jun 2024 |
Luteolin for the Treatment of People With Schizophrenia
University of Maryland, Baltimore
Schizophrenia
Schizoaffective Disorder
Luteolin is a natural product found in foods such as celery, green pepper, parsley, and
chamomile tea. It has been found to have anti-cancer, anti-oxidant, and anti-inflammatory
properties. The purpose of this study is to determine if luteolin helps improve symptoms
of schizophrenia. expand
Luteolin is a natural product found in foods such as celery, green pepper, parsley, and chamomile tea. It has been found to have anti-cancer, anti-oxidant, and anti-inflammatory properties. The purpose of this study is to determine if luteolin helps improve symptoms of schizophrenia. Type: Interventional Start Date: Jun 2022 |
Diaphragm Structure and Function in Children
University of Maryland, Baltimore
Respiratory Muscle Training
The purpose of this research is to study the feasibility of a specific training program
for the breathing muscles (inspiratory muscle training) and the effects on how breathing
is regulated during exercise in typically developing children. expand
The purpose of this research is to study the feasibility of a specific training program for the breathing muscles (inspiratory muscle training) and the effects on how breathing is regulated during exercise in typically developing children. Type: Interventional Start Date: Mar 2024 |
Cognitive Behavioural Therapy to Optimize Post-Operative Recovery Trial
McMaster University
Pain, Postoperative
Pain, Acute
Pain, Chronic
Fractures, Closed
Fractures, Open
Psychological factors such as stress, distress, anxiety, depression, and poor coping
strategies may be associated with ongoing pain following injuries such as fractures. To
study this relationship, patients will undergo cognitive behavioural therapy (CBT) which
is designed to modify such thoughts... expand
Psychological factors such as stress, distress, anxiety, depression, and poor coping strategies may be associated with ongoing pain following injuries such as fractures. To study this relationship, patients will undergo cognitive behavioural therapy (CBT) which is designed to modify such thoughts with the goal of reducing ongoing pain and improving quality of life. The goal of this study is to determine if CBT, versus usual care, reduces the prevalence of moderate to severe persistent post-surgical pain (PPSP) over 12-months post-fracture in patients with an open or closed fracture of the appendicular skeleton, treated with internal fixation. Type: Interventional Start Date: Jan 2021 |
Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy
Dennis M. McNamara, MD, MS
Peripartum Cardiomyopathy, Postpartum
The study will enroll 200 women newly diagnosed with peripartum cardiomyopathy within 5
months postpartum in a randomized placebo controlled trial of bromocriptine therapy to
evaluate its impact on myocardial recovery and clinical outcomes. Given that
bromocriptine prevents breastfeeding, an additional... expand
The study will enroll 200 women newly diagnosed with peripartum cardiomyopathy within 5 months postpartum in a randomized placebo controlled trial of bromocriptine therapy to evaluate its impact on myocardial recovery and clinical outcomes. Given that bromocriptine prevents breastfeeding, an additional 50 women with peripartum cardiomyopathy excluded from the trial due to a desire to continue breastfeeding but meeting all other entry criteria will be followed in an observational cohort. Type: Interventional Start Date: Jul 2022 |
ICG Fluorescence Imaging in Open Fracture Trauma Patients
Dartmouth-Hitchcock Medical Center
Trauma Injury
This is a prospective observational study that will evaluate the association between bone
and tissue perfusion, as measured by indocyanine green (ICG) fluorescence imaging, and
complications, in an effort to develop ICG fluorescence imaging as a diagnostic tool to
quantitatively guide operative debridement. expand
This is a prospective observational study that will evaluate the association between bone and tissue perfusion, as measured by indocyanine green (ICG) fluorescence imaging, and complications, in an effort to develop ICG fluorescence imaging as a diagnostic tool to quantitatively guide operative debridement. Type: Observational [Patient Registry] Start Date: Oct 2020 |
Blood Donor CVD 5000
University of Maryland, Baltimore
Risk Reduction
This is an open-label, non-randomized study. Volunteers will be vaccinated with the
typhoid oral vaccine, Vivotif. Vivotif has been licensed by the Food and Drug
Administration (FDA) for travelers to developing countries. Volunteers will also be asked
to provide blood, saliva, and stool specimens... expand
This is an open-label, non-randomized study. Volunteers will be vaccinated with the typhoid oral vaccine, Vivotif. Vivotif has been licensed by the Food and Drug Administration (FDA) for travelers to developing countries. Volunteers will also be asked to provide blood, saliva, and stool specimens over a follow-up time period of up to eight years. The specimens obtained in this clinical research study will be used to further the investigator's understanding of the protective immunological mechanisms that can be elicited systemically and may be applicable to other enteric pathogens. Type: Interventional Start Date: Jan 2004 |
APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO)
Wake Forest University Health Sciences
Kidney Diseases
Kidney Failure
Kidney Disease, Chronic
The APOLLO study is being done in an attempt to improve outcomes after kidney
transplantation and to improve the safety of living kidney donation based upon variation
in the apolipoprotein L1 gene (APOL1). Genes control what is inherited from a family,
such as eye color or blood type. Variation in... expand
The APOLLO study is being done in an attempt to improve outcomes after kidney transplantation and to improve the safety of living kidney donation based upon variation in the apolipoprotein L1 gene (APOL1). Genes control what is inherited from a family, such as eye color or blood type. Variation in APOL1 can cause kidney disease. African Americans, Afro-Caribbeans, Hispanic Blacks, and Africans are more likely to have the APOL1 gene variants that cause kidney disease. APOLLO will test DNA from kidney donors and recipients of kidney transplants for APOL1 to determine effects on kidney transplant-related outcomes. Type: Observational Start Date: Mar 2019 |
Traditional Versus Early Aggressive Therapy for Multiple Sclerosis Trial
Johns Hopkins University
Multiple Sclerosis, Relapsing-Remitting
FDA-approved multiple sclerosis (MS) disease-modifying therapies (DMTs) target the
relapsing phase of MS but have minimal impact once the progressive phase has begun. It is
unclear if, in the relapsing phase, there is an advantage of early aggressive therapy
with respect to preventing long-term disability.... expand
FDA-approved multiple sclerosis (MS) disease-modifying therapies (DMTs) target the relapsing phase of MS but have minimal impact once the progressive phase has begun. It is unclear if, in the relapsing phase, there is an advantage of early aggressive therapy with respect to preventing long-term disability. The infectious risks and other complications associated with higher-efficacy treatments highlight the need to quantify their effectiveness in preventing disability. The TRaditional versus Early Aggressive Therapy for MS (TREAT-MS) trial is a pragmatic, randomized controlled trial that has two primary aims: 1) to evaluate, jointly and independently among patients deemed at higher risk vs. lower risk for disability accumulation, whether an "early aggressive" therapy approach, versus starting with a traditional, first-line therapy, influences the intermediate-term risk of disability, and 2) to evaluate if, among patients deemed at lower risk for disability who start on first-line MS therapies but experience breakthrough disease, those who switch to a higher-efficacy versus a new first-line therapy have different intermediate-term risk of disability. Type: Interventional Start Date: May 2018 |
CT TAVR Abdomen Study
University of Maryland, Baltimore
Transcatheter Aortic Valve Replacement
A standard polyenergetic CT (computed tomography) procedure utilizes 100 ml of iodinated
contrast. A recent world-wide shortage of iodine based intravenous contrast has
highlighted the need to search for alternative methods or doses. Reducing iodinated IV
contrast dose can mitigate IV contrast supply... expand
A standard polyenergetic CT (computed tomography) procedure utilizes 100 ml of iodinated contrast. A recent world-wide shortage of iodine based intravenous contrast has highlighted the need to search for alternative methods or doses. Reducing iodinated IV contrast dose can mitigate IV contrast supply shortages and enable significant cost savings for the radiology practice and hospital system. In addition, decreased IV contrast dose can potentially reduce the rate of acute kidney injury, specifically in patients with decreased renal function. The purpose of the study is to determine whether low IV contrast dose CT with monoenergetic reconstruction can be use for presurgical planning of transcatheter valve replacement (TAVR) procedure. Type: Interventional Start Date: Sep 2023 |
Evaluation of a New Strategy for Protocolized Antibiotic Care for Severe Open Fractures: SEXTANT
Major Extremity Trauma Research Consortium
Post Operative Surgical Site Infection
The proposed study is a multi-center, prospective randomized controlled trial comparing
current standard of care treatment to the SEXTANT treatment protocol in patients with
Type III open fractures of the tibia and IIIB fractures of the ankle and hindfoot. expand
The proposed study is a multi-center, prospective randomized controlled trial comparing current standard of care treatment to the SEXTANT treatment protocol in patients with Type III open fractures of the tibia and IIIB fractures of the ankle and hindfoot. Type: Interventional Start Date: May 2021 |
Partners in Children's Health (CSN): A Randomized Trial of an Attachment Based Intervention
University of Maryland, Baltimore
Respiratory Disease
Inflammation
Insufficient Sleep
Digestive Disease
Skin Conditions
The goal of this randomized controlled trial is to evaluate the impacts of an
attachment-based intervention (Attachment Biobehavioral Catch-Up (ABC) and Home
Book-of-the-Week (HBOW) program on emerging health outcomes (i.e., common childhood
illnesses, body mass index, and sleep) in low-income Latino... expand
The goal of this randomized controlled trial is to evaluate the impacts of an attachment-based intervention (Attachment Biobehavioral Catch-Up (ABC) and Home Book-of-the-Week (HBOW) program on emerging health outcomes (i.e., common childhood illnesses, body mass index, and sleep) in low-income Latino children (N=260; 9 months at enrollment). It is hypothesized that children randomized to ABC will have better health outcomes in comparison to the HBOW control group. Type: Interventional Start Date: Oct 2023 |
Targeting Emotion Dysregulation to Reduce Suicide in People With Psychosis
University of Maryland, Baltimore
Psychosis
Suicide
People with psychotic disorders are excluded from most suicide-focused clinical trials
despite incredibly high rates of completed suicide, and interventions that have been
tested for this population have shown limited impact on suicide. Emotion dysregulation is
a significant suicidogenic factor that... expand
People with psychotic disorders are excluded from most suicide-focused clinical trials despite incredibly high rates of completed suicide, and interventions that have been tested for this population have shown limited impact on suicide. Emotion dysregulation is a significant suicidogenic factor that is understudied in people with psychotic disorders. The investigators propose to implement and evaluate an intervention targeting emotion dysregulation in people with psychotic disorders while employing rigorous statistical modeling and measurement techniques including Ecological Momentary Assessment, which will support future advanced research on suicide and suicide prevention for this high-risk group. Type: Interventional Start Date: Dec 2022 |
ROSE-Longitudinal Assessment With Neuroimaging
University of Cincinnati
Intracerebral Hemorrhage
The investigators will perform follow-up on 250 of 500 cases recruited into the ROSE
study of cases with deep and lobar intracerebral hemorrhage to perform advanced
neuroimaging at 12-24 months post stroke, and evaluations of motor and cognitive function
at baseline, 6 months after baseline, and 12... expand
The investigators will perform follow-up on 250 of 500 cases recruited into the ROSE study of cases with deep and lobar intracerebral hemorrhage to perform advanced neuroimaging at 12-24 months post stroke, and evaluations of motor and cognitive function at baseline, 6 months after baseline, and 12 months after baseline to determine predictors of recovery, progressive cognitive or functional impairment. The investigators propose to leverage the recruitment, DNA, RNA-seq and baseline advanced neuroimaging cohort of ROSE to obtain long-term neuroimaging and identical assessments longitudinally to address critical questions regarding the progressive decline of patients 12 to 24 months post intracerebral hemorrhage (ICH) with long term cognitive follow-up to 36 months on average. This proposal would represent the largest, and longest advanced neuroimaging and RNA-sequencing evaluation after ICH to date. Type: Observational Start Date: Sep 2020 |
2-level Cervical Disc Replacement Comparing Prodisc C SK & Vivo to Mobi-C
Centinel Spine
Symptomatic Cervical Disc Disease
A multi-center, prospective, randomized, controlled comparison of the prodisc C SK and
prodisc C Vivo to the control, a similar, legally marketed total disc replacement device
in subjects with symptomatic cervical disc disease (SCDD). expand
A multi-center, prospective, randomized, controlled comparison of the prodisc C SK and prodisc C Vivo to the control, a similar, legally marketed total disc replacement device in subjects with symptomatic cervical disc disease (SCDD). Type: Interventional Start Date: Aug 2019 |
A Study to Customize Ibrutinib Treatment Regimens for Participants With Previously Untreated Chronic...
Janssen Research & Development, LLC
Leukemia, Lymphocytic, Chronic, B-Cell
Small Lymphocytic Lymphoma
The purpose of this study is to evaluate the efficacy and safety of ibrutinib +
venetoclax (I+V) and ibrutinib monotherapy regimens in which dosing of ibrutinib is
either proactively reduced or reactively modified in response to adverse events (AEs). expand
The purpose of this study is to evaluate the efficacy and safety of ibrutinib + venetoclax (I+V) and ibrutinib monotherapy regimens in which dosing of ibrutinib is either proactively reduced or reactively modified in response to adverse events (AEs). Type: Interventional Start Date: Jan 2024 |
Program to Assess Adverse Events and Change in Disease Activity of Oral Upadacitinib in Adult Participants...
AbbVie
Systemic Lupus Erythematosus
Systemic Lupus Erythematosus (SLE) is an immune-mediated disease associated with
inflammation of multiple organ systems. This study will assess how safe and effective
upadacitinib is in treating adult participants with moderately to severely active SLE.
Adverse events and change in the disease activity... expand
Systemic Lupus Erythematosus (SLE) is an immune-mediated disease associated with inflammation of multiple organ systems. This study will assess how safe and effective upadacitinib is in treating adult participants with moderately to severely active SLE. Adverse events and change in the disease activity will be assessed. Upadacitinib is an approved drug for rheumatoid arthritis, psoriatic arthritis, and axial spondylarthritis and is being developed for the treatment of SLE. This study is "double-blinded", which means that neither the trial participants nor the study doctors will know who will be given upadacitinib and who will be given placebo (does not contain treatment drug) . This study comprised of 3 sub studies. In Study 1 and Study 2, study doctors put the participants in 1 of the 2 groups, called treatment arms. Each group receives a different treatment. There is a 1 in 2 chance that participants will be assigned to placebo. Eligible participants from Study 1 and Study 2 will enter Study 3 at week 52 to receive specific doses of upadacitinib based on their disease activity and their original treatment assignment in Study 1 or 2. Approximately 500 participants diagnosed with SLE will be enrolled in each of the Study 1 and Study 2 in approximately 320 sites across the world. Participants will receive oral tablets of upadacitinib or matching placebo once daily for 52 weeks in Study 1 and Study 2. Eligible participants from Study 1 and Study 2 will receive oral tablets of upadacitinib once daily for 52 weeks in Study 3. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, checking for side effects and completing questionnaires. Type: Interventional Start Date: Jul 2023 |
A Prospective and Retrospective Observational Study of Multidrug-Resistant Patient Outcomes With and...
Theratechnologies
HIV Infections
Multi-Antiviral Resistance
The virological efficacy of ibalizumab has been clearly demonstrated in multiple clinical
trials. This study will expand ibalizumab's clinical data set and allow a better
understanding of the virologic response durability on ARV regimens with or without
ibalizumab in a heterogeneous real-world patient... expand
The virological efficacy of ibalizumab has been clearly demonstrated in multiple clinical trials. This study will expand ibalizumab's clinical data set and allow a better understanding of the virologic response durability on ARV regimens with or without ibalizumab in a heterogeneous real-world patient population. Additional data on the efficacy and safety of ibalizumab and its impact on patient reported outcomes will be captured until study end. Primary Objective: To evaluate the long-term efficacy, safety, and durability of ibalizumab in combination with other ARVs by comparing the virologic, immunologic and clinical outcomes of patients receiving ibalizumab treatment versus patients not receiving ibalizumab. Secondary Objective: To assess the efficacy of ibalizumab in combination with other antiretrovirals by comparing the virologic, immunologic, clinical and patient reported outcomes of patients before and after they receive ibalizumab treatment. To assess the long-term safety and tolerability of ibalizumab. Other Objectives: To assess risk factors/predictors of virologic and immunologic response. To assess efficacy and safety in special populations that enroll. Type: Observational Start Date: Mar 2022 |
Blood-Brain Barrier Disruption (BBBD) for Liquid Biopsy in Subjects With GlioBlastoma Brain Tumors
InSightec
Glioblastoma
Glioma
Liquid Biopsy
The purpose of this study is to evaluate the safety and efficacy of targeted blood brain
barrier disruption with Exablate Model 4000 Type 2.0/2.1 for liquid biopsy in subjects
with suspected Glioblastoma brain tumors expand
The purpose of this study is to evaluate the safety and efficacy of targeted blood brain barrier disruption with Exablate Model 4000 Type 2.0/2.1 for liquid biopsy in subjects with suspected Glioblastoma brain tumors Type: Interventional Start Date: Aug 2022 |
The Society for Obstetric Anesthesia and Perinatology Research Network General Anesthesia Registry
Yale University
Cesarean Delivery
General Anesthesia
The SOAP registry is a prospective, multicenter, electronic registry. The goal is to
investigate the indications, mode of airway management, predisposing factors, and
obstetric and anesthetic outcomes of pregnant patients who receive general anesthesia for
cesarean delivery. expand
The SOAP registry is a prospective, multicenter, electronic registry. The goal is to investigate the indications, mode of airway management, predisposing factors, and obstetric and anesthetic outcomes of pregnant patients who receive general anesthesia for cesarean delivery. Type: Observational Start Date: Feb 2024 |
Post Approval Study - Evaluate the Long-Term Safety and Effectiveness of the WEB Device
Microvention-Terumo, Inc.
Wide Neck Bifurcation Intracranial Aneurysms
A prospective, multicenter, single arm, interventional study. The target patient
population for this study are adult subjects with WNBAs of the anterior and posterior
intracranial circulation. The primary effectiveness outcome of the study is adequate
intracranial aneurysm occlusion on the 1 year... expand
A prospective, multicenter, single arm, interventional study. The target patient population for this study are adult subjects with WNBAs of the anterior and posterior intracranial circulation. The primary effectiveness outcome of the study is adequate intracranial aneurysm occlusion on the 1 year angiogram as adjudicated by a core laboratory. Type: Interventional Start Date: Aug 2022 |
LITT Followed by Hypofractionated RT for Newly Diagnosed Gliomas (GCC 20138)
University of Maryland, Baltimore
Glioma
Glioblastoma
Brain Tumor
The purpose of this study is to evaluate the treatment regimen of using Laser
Interstitial Thermal Therapy (LITT) and Hypo-fractionated Radiation Therapy to treat
patients with newly diagnosed gliomas. expand
The purpose of this study is to evaluate the treatment regimen of using Laser Interstitial Thermal Therapy (LITT) and Hypo-fractionated Radiation Therapy to treat patients with newly diagnosed gliomas. Type: Interventional Start Date: Feb 2021 |
Pilot Testing the Check Up
University of Maryland, Baltimore
Cannabis Use Disorder
We propose to pilot test an adapted version of the Teen Marijuana Check Up (TMCU) for
persistent cannabis users with first episode psychosis (FEP) in Coordinated Specialty
Care (CSC). The adapted version of the TMCU will include tailoring to risks of persistent
cannabis use in FEP, providing education... expand
We propose to pilot test an adapted version of the Teen Marijuana Check Up (TMCU) for persistent cannabis users with first episode psychosis (FEP) in Coordinated Specialty Care (CSC). The adapted version of the TMCU will include tailoring to risks of persistent cannabis use in FEP, providing education on lower risk cannabis use, and adding a session to address collaborative planning to maintain CSC engagement and antipsychotic adherence and to reduce harm associated with cannabis use. Type: Interventional Start Date: Jan 2021 |
Topical Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures At High Risk of...
Major Extremity Trauma Research Consortium
Post Operative Surgical Site Infection
The overall objective is to compare the effect of Vancomycin and Tobramycin powder
combined (treatment) to Vancomycin powder (control) in the reduction of post-fixation
infections of tibial plateau and tibial pilon fractures at high risk of infection
(collectively considered the "study injuries"). expand
The overall objective is to compare the effect of Vancomycin and Tobramycin powder combined (treatment) to Vancomycin powder (control) in the reduction of post-fixation infections of tibial plateau and tibial pilon fractures at high risk of infection (collectively considered the "study injuries"). Type: Interventional Start Date: May 2021 |
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