University of Maryland, Baltimore

• These include patients with: 1. Severe uncontrolled neuropathic pain due to radiculopathy or radicular injury 2. Spinal Cord Injury 3. Phantom Limb Pain Patients that have had prior motor cortex stimulation or spinal cord stimulators will be eligible provided that the hardware has been removed at least six months ago. Detailed inclusion and

for the study are listed below: Inclusion criteria: 1. Age greater than 21 and less than 75 years 2. Subjects who are able and willing to give consent and able to attend all study visits, 3. Documented Neuropathic pain for more than 6 months duration, confirmed from clinical history and examination by a pain specialist or neurologist 4. Failure to respond to any of the usual therapeutic regimens considered to be standard of care for neuropathic pain. The patient should have failed a trial of at least three pain medications, including at least one opioid agent 5. Patients with radiculopathy or radicular injury or phantom limb pain should have failed one additional pain intervention such as nerve block, epidural steroid injection, motor cortex or spinal cord stimulator 6. Patients with Spinal cord injury, in addition to having failed a trial of three pain medications, should have failed one additional intervention such as Botox injection or intra-thecal baclofen. 7. Subjects should have been on stable dose of analgesic agents for at least a period of 4 weeks 8. Clinical symptoms consistent with persistent, intractable pain that has remained at average NRS score >5 for 30 days, significant pain related disability (Pain Disability Index (PDI) score >30) or severe allodynia. 9. Central lateral thalamotomy is feasible based on evaluation of imaging studies 10. Patient able to communicate sensations during the ExAblate TcMRgFUS treatment 11. Two members of the medical team have agreed upon inclusion and exclusion criteria. Exclusion Criteria: 1. Patient with contra-indications to MRI such as severe claustrophobia and metallic implants incompatible with MRI. 2. Severe psychiatric disorder such as uncontrolled depression, bipolar disorder, prior attempt at suicide or suicide ideation in preceding 12 months 3. Life expectancy less than 12 months 4. Anticoagulant or antiplatelet medications as well as underlying coagulopathy 5. Prior or currently implanted thalamic DBS 6. Pregnant ladies or women of childbearing age who are sexually active and not using contraception 7. Inability to provide informed consent, for example due to underlying cognitive impairment or aphasia 8. Presence of intracranial mass or an acute intracranial abnormality 9. Subjects with unstable cardiac status such as Unstable angina pectoris, documented myocardial infarction within 6 months of protocol entry and ejection fraction less than 40 10. Subjects exhibiting any behavior(s) consistent with ethanol or substance abuse as defined by the criteria outlined in the DSM-IV as manifested by one (or more) of the following occurring within a 12 month period: 1. Recurrent substance use resulting in a failure to fulfill major role obligations at work, school, or home (such as repeated absences or poor work performance related to substance use; substance-related absences, suspensions, or expulsions from school; or neglect of children or household). 2. Recurrent substance use in situations in which it is physically hazardous (such as driving an automobile or operating a machine when impaired by substance use) 3. Recurrent substance-related legal problems (such as arrests for substance related disorderly conduct) 4. Continued substance use despite having persistent or recurrent social or interpersonal problems caused or exacerbated by the effects of the substance (for example, arguments with spouse about consequences of intoxication and physical fights). 11. Severe hypertension (diastolic BP > 100 on medication or persistently elevated SBP>140 mmHg despite antihypertensive medications) 12. History of immunocompromise including those who are HIV positive. 13. History of CNS disease (this includes but not limited to intracranial hemorrhage, Traumatic brain injury or thalamic stroke, seizures within the past year, brain tumors, multiple CVA or CVA within 6 months) 14. Subjects with life-threatening systemic disease that include and not limited to the following will be excluded from the study participation: HIV, Liver Failure, blood dyscrasias, etc. 15. Individuals who are not able or willing to tolerate the required prolonged stationary supine position during treatment (can be up to 4 hrs of total table time.) 16. Are participating or have participated in another clinical trial in the last 30 days 17. Patients receiving a Morphine equivalent dose of greater than 90 mg per day 18. Subjects who have non-neuropathic pain as the major component of their pain presentation will be excluded from the study.