Diaphragm Structure and Function in Childhood Cancer Survivors
The purpose of this research is to study the feasibility of a specific training program for the breathing muscles (inspiratory muscle training) and the effects on how breathing is regulated during exercise in childhood cancer survivors.
- Childhood Cancer
- Cancer Survivors
- Eligible Ages
- Between 6 Years and 12 Years
- Eligible Genders
- Accepts Healthy Volunteers
- Completed medical treatment (chemotherapy, chemotherapy/surgery, chemotherapy/radiation or any combination of cancer treatment) for any type of cancer, except for cancer of the central nervous system, at least 1 year ago
- History of neuromuscular, cardiac, or pulmonary disease prior to the diagnosis of cancer - Recent injury or condition (less than 6 months ago) that precludes strength testing or walking - Dyspnea with minimal activity (4 on the modified Medical Research Council Dyspnea Scale)
- Study Type
- Intervention Model
- Single Group Assignment
- Primary Purpose
- Supportive Care
- None (Open Label)
Inspiratory Muscle Training (IMT)
|Participants will be asked to perform inspiratory muscle training (breathing exercise) 5 days per week for 6 weeks at home.
- University of Maryland, Baltimore
Study ContactMartina Miller
During the first study visit, participants will undergo a series of pulmonary function and muscle performance tests followed by treadmill walking trials at different speeds with concurrent expired gas analysis via a face mask. The participants will then perform a training program for the breathing muscles at home for 6 weeks. The research team will follow up each week via telehealth visits to support training. After the 6-week training program, participants will return in-person for a follow-up visit and will undergo the same series of assessments as the first visit.